pentobarbital will lessen the level or result of buprenorphine, prolonged-acting injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Sufferers who transfer to buprenorphine extensive-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers needs to be monitored to be